Peter Bruenker,Tanja Fauti,Christiane Neumann,Christian Klein,Pablo Umaña
申请号：
US14434168
公开号：
US10087250B2
申请日:
2013.10.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to bispecific antibodies comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen； and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged and the two Fab fragments are connected to each other by two peptide linkers； and wherein the bispecific antibody is devoid of a Fc domain； methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
