compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and method for the treatment or prophylaxis of HIV infection or for the treatment, prophylaxis, or delay in the onset or progression of AIDS in a patient in need thereof.
DAI-SHI SU,DAVID C. DUBOST,ERIC J. CHOI,JOHN S. WAI,MARK W. EMBREY,PETER D. WILLIAMS,RICHARD C. A. ISAACS,RICHARD G. BALL,SARAH L. TRICE,SHANKAR VENKATRAMAN,TAO PEI,THORSTEN E. FISHER,WAYNE J. THOMPSO
申请号：
BRPI0920605
公开号：
BRPI0920605A2
申请日:
2009.10.02
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.
