Methods and apparatuses for wireless communication between medical devices are provided. In some embodiments, commodity low power, low bandwidth communication protocols may be utilized to simultaneously convey multiple signals with high fidelity and reliability. For example, cardiac sound data and ECG data may be compressed using a common ADPCM component and inserted into a common BLE packet structure. Command-control data may also be inserted. Where required command-control data reporting frequency is less than the packet frequency, header bits may be utilized to convey multiple types of command-control data in a given packet byte position. Rolling packet sequence values may be inserted into the common packet structure, for use by receiving devices to identify link integrity failures.
