Methods for producing self-compositions useful in the treatment of injured and / or injured connective tissue, chronic dry skin, chronic muscle rupture and / or chronic degenerative joint disease and inflammatory skin disorders in mammals are described. Such a method comprises the step of producing an anti-inflammatory / anti-catabolic component of a self-composition comprising IL-lra and TIMP. Collecting blood from the mammal； Delivering blood to the tube； Incubating the blood for a period of about 24 hours at a temperature of about 37 캜 to about 39 캜, preferably in the presence of sodium citrate； Centrifuging the blood to separate the blood into a supernatant component and a cell fraction； And collecting the supernatant component to produce an anti-inflammatory / anti-catabolic component. Such methods include collecting blood from a mammal； Delivering the blood to the tube in the presence of about 4% citric acid； Centrifuging the blood to separate platelet-rich plasma components from whole blood； Collecting a platelet-rich plasma component； And mixing the supernatant component with a platelet-rich plasma component to provide a self-composition. Methods of treating damaged and / or wounded connective tissue, chronic dryness, chronic muscle tear and / or chronic degenerative joint pathology and inflammatory skin disorders in a subject with such a self-composition, methods of treating damaged and / or injured connective tissue Chronic and / or chronic degenerative arthritis and inflammatory skin disorders, and a method for treating damaged and / or wounded connective tissue, chronic diarrhea, chronic muscle rupture and / or chronic Use of such a self-composition for the treatment of degenerative arthritic conditions and inflammatory skin disorders is also provided.포유동물에서의 손상되고/되거나 상처를 입은 결합 조직, 만성 건증, 만성 근육 파열 및/또는 만성 퇴행성 관절 병태 및 염증성 피부 장애의 치료에 유용한 자가 조성물을 생산하는 방법이 기술된다. 이러한 방법은 IL-1ra 및 TIMP를 포함하는 자가 조성물의 항염증/항이화 성분을 제조하는 단계를 포함한다. 포유동물로부터 혈액을 수집하는 단계； 혈액을 튜브로 전달하
