The Board of Trustees of the Leland Stanford Junior University
发明人:
HUTTNER, Melanie,WENDER, Paul,CEGELSKI, Lynette,ZANG, Xiaoyu,ANTONOPLIS, Alexandra
申请号：
AU2019225938
公开号：
AU2019225938A1
申请日:
2019.02.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Antibiotic agents conjugated to a guanidinium-rich molecular transporter (GR-MoTr) are provided. The drug conjugates show surprising increases in efficacy compared to the unconjugated drug in difficult-to-treat bacterial infections including biofilms, stationary and persister cells, and multi-drug resistant bacteria, as well as intracellular bacteria.
