Formula (I) Compounds and their salts (I) in which R1,R2,R3 and A are defined in this document. Formula (I) compounds and their salts have been found to hinder the binding of the Bet protein family containing bromine A.For instanceAcetyllysine residues andTherefore,They can be used in treatment.For instanceIn the treatment of self-immunity and inflammation,For example, rheumatoid arthritisAnd the presence of formula cancer (I) and salt: formula (I) Wherein R1,R2,R3 and a are as defined here. Compounds of formula (I) and salts have been found to inhibit the binding of the bet family of bromodomain containing proteins to,For example,Acetylated Lysine Residues and So may have used in these rapies,For example in the treatment of autimmune and inflammatory diseases,Such as Rheumatid arthritis；And cancer.Compuestos de fórmula (I) y sales de los mismos (I) en la que R1, R2, R3 y a son como se definen en el presente documento. Se ha descubierto que los compuestos de fórmula (I) y sales de los mismos inhiben la unión de la familia BET de proteínas que contienen bromodominios a, por ejemplo, residuos de lisina acetilados y, por tanto, pueden tener uso en terapia, por ejemplo, en el tratamiento de enfermedades autoinmunitarias e inflamatorias, tales como artritis reumatoide； y cánceresCompounds of formula (I) and salts thereof: Formula (I) wherein R1, R2, R3 and a are as defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis； and cancers.
