The present invention provides, among other things, effective oral formulations based on desazadesferrithiocin polyether (DADFT-PE) analogues, salts and polymorphs thereof, as well as their application for treatment of metal overload, in particular, iron overload, and associated diseases, disorders and conditions.La présente invention concerne, entre autres, des formulations orales efficaces à base danalogues de désazadesferrithiocine polyéther (DADFT-PE), de sels et de polymorphes de ceux-ci, ainsi que leur application pour le traitement dune surcharge en métal, en particulier dune surcharge en fer, et de maladies, troubles et affections associés.