BROGGINI, Diego Fernando Domenico,BROGGINI DIEGO FERNANDO DOMENICO
申请号：
CL2017002022
公开号：
CL2017002022A1
申请日:
2017.08.08
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
Dissemination:1. A formaldehyde scrubber is used to enhance n - (3,5-methoxyphenyl) - n '(1-methylethyl) - N - [3 - (1-methyl-1h-pirazol-4-il) quinoxalin-6-il] ethan-1, 2-diamine, a salt or solution acceptable on the drug, which is contained in the solid drug composition.A method for avoiding, delaying, slowing down or reducing N - (3,5-methoxyphenyl) - N - (1-methylethyl) - N - [3 - (1-methyl-1-pyrazol-4-one) quinoxalin-6-il] ethane-1,2-diamine, a pharmaceutically acceptable salt or a solution contained therein, in 6, 8 - (1-methyl) 4 - (1-methyl) 1 - [3 - (1-methyl-1h-pyrazol-4-il) quinoxalin-6-il] - 2, 3, 4, 5-tetrahydro-1h-1, 4-benzodiazepine-zepina, a salt or solution acceptable for drugs.Drug ingredients include n - (3,5-methoxybenzene) n '(1-methyl) n - [3 - (1-methyl-1h-pyrazol-4-il) quinoxalin-6-il] etan-1, 2-diamin, a salt or solution acceptable on drugs, a formaldehyde detergent, and a carrier acceptable on drugs.A method of treating cancer in a patient, including managing the patient's pharmaceutical ingredients； andUse of pharmaceutical ingredients.Se divulga:El uso de un depurador de formaldehido para aumentar la estabilidad química de N-(3,5-dimetoxifenil)-N’-(1-metiletil)-N-[3-(1-metil-1H-pirazol-4-il)quinoxalin-6-il]etan-1,2-diamina, una sal farmacéuticamente aceptable de la misma o un solvato de la misma, contenida en la composición farmacéutica sólida. Un método para evitar, posponer, ralentizar o disminuir la transformación de N-(3,5-dimetoxifenil)-N’-(1-metiletil)-N-[3-(1-metil-1H-pirazol-4-il)quinoxalin-6-il]etan-1,2-diamina, una sal farmacéuticamente aceptable de la misma o un solvato de la misma, contenida en una composición farmacéutica, en 6,8-dimetoxi-4-(1-metiletil)-1-[3-(1-metil-1H-pirazol-4-il)quinoxalin-6-il]-2,3,4,5-tetrahidro-1H-1,4-benzodiazepina, una sal farmacéuticamente aceptable de la misma o un solvato de la misma. Una composición farmacéutica que comprende N-(3,5-dimetoxifenil)-N’-(1-metiletil)-N-[3-(1-metil-
