Robert Boeckman,Brendan Boyce,Lifeng Xiao,Zhingqiang Yao,Frank H. Ebetino
申请号:
US15772893
公开号:
US20180318282A1
申请日:
2016.11.02
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides compositions and methods for providing controllable local delivery of a conjugate of chloroquine (CQ) and a bisphosphonate to treat diseases characterized by abnormal bone metabolism. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.