PROBLEM TO BE SOLVED: To provide a pharmaceutical composition capable of alleviating gastric mucosa disorder caused by non-steroidal antipyretic analgesic antiphlogistic.SOLUTION: This invention relates to a pharmaceutical composition containing tranexamic acid and sporogenic lactobacillus, and used as a therapeutic agent for gastric mucosa disorder caused by non-steroidal antipyretic analgesic antiphlogistic and/or ulcer.