THOMAS JEFFERSON UNIVERSITY;UNIVERSITY OF MARYLAND EASTERN SHORE;UNIVERSITY OF MARYLAND, BALTIMORE
发明人:
ABHIJIT GODBOLE,ANDREW KWEGYIR-AFFUL,LALJI K. GEDIYA,PURANIK PURUSHOTTAMACHAR,TADAS VASAITIS,VINCENT C.O. NJAR
申请号：
BR112015023098
公开号：
BR112015023098A2
申请日:
2014.03.14
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Summary "Androgen Receptor Down-Regulating Agents and Uses thereof" The present invention relates to the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen (air) receptor, both full length and splicing variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional air.resumo “agentes de infrarregulação do receptor de andrógeno e usos dos mesmos” a presente invenção refere-se ao design e síntese de novos compostos esteroidais que causam a infrarregulação do receptor de andrógeno (ar), tanto de comprimento total quanto a variante de splicing. os compostos são agentes potenciais para o tratamento de todas as formas de câncer da próstata e outras doenças que dependem do ar funcional.
