A medical device, such as an introducer, includes a shaft having a lumen therethrough. A distal region of the shaft includes both a fixed curve region and a steerable region. According to certain aspects of the disclosure, the fixed curve region is more proximal than the steerable region. The fixed curvature of the distal region is selected to facilitate positioning of the distal end of the medical device in the general vicinity of a target, such as the left atrial appendage, while the steerable region allows for &ldquofine tuning.&rdquo The lumen of the shaft is a large bore, typically on the order of about 12F to about 14F, to facilitate passage of larger medical devices, including left atrial appendage occlusion devices.
