The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, breast, urogenital, gastric, colorectal, cervical, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors. In still other embodiments the liposomes can deliver other drugs, including atropine for treatment of organophosphate poisoning.本發明為藥物傳遞之領域,且具體而言,為基於陽離子脂質體之藥物傳遞。在實施例中,本發明提供製備適用於將脂質體傳遞至腫瘤(包括腦腫瘤)之配位體靶向之(例如,抗體或抗體片段靶向之)脂質體的方法。在實施例中,該等脂質體傳遞替莫唑胺跨越血腦障壁以用於治療原發性或轉移性腦腫瘤。可用該等脂質體來治療之其他癌症包括:神經內分泌腫瘤、黑素瘤、前列腺癌、頭頸部癌、卵巢癌、肺癌、肝癌、乳癌、泌尿生殖系統癌、胃癌、結腸直腸癌、宮頸癌、脂肉瘤、橫紋肌肉瘤、絨毛膜癌、胰腺癌、視網膜母細胞瘤以及其他類型之癌症。在另一實施例中,該等脂質體傳遞美法侖以用於治療多發性骨髓瘤、其他血液腫瘤、或其他實體腫瘤。在其他實施例中,該等脂質體可傳遞包括阿托品之其他藥物以用於治療有機磷中毒。
