Compounds (e.g., macrocyclic compounds) can modulate biological processes, for example, through binding to a host Protein (For example, a member of the FKBP Family, a member of the family of cyclophilins or Pin1) and a Target Protein (e.g.A Target Protein eukaryotic mammalian target such as a Protein or a Protein Target a Target Protein prokaryotic fungal or bacterial) such as a Target Protein.These compounds bind with presenting endogenous intracellular Proteins, such as fkbps or ciclofilinas and the resulting Binary complexes selectively bind and modulate the activity of intracellular Target Proteins.The formation of a complex between the Tripartite Protein Anchor, the compound and the target Protein is handled by Interactions of protein - protein - Protein compound and both are required for the Modulation of the activity of target Proteins.In some forms of realization, the compounds \"Reprogram\" The Union of the antigen-presenting Proteins with Target Proteins that did not bind with the Protein normally host (For example, show no detectable Union in Mammalian Cells without Compound).In some forms of realization, the compounds provided \"Reprogram\" The Union with the host Protein to broadly enhance the interaction with a particular Target can have some interaction with the absence of compound. Interactions achieved through such rescheduling result in an ability to modulate the activity of these targets.Compuestos (por ejemplo, compuestos macrocíclicos) capaces de modular procesos biológicos, por ejemplo, a través de la unión con una proteína presentadora (por ejemplo, un miembro de la familia FKBP, un miembro de la familia de las ciclofilinas o PIN1) y una proteína diana (por ejemplo, una proteína diana eucariota tales como una proteína diana de mamífero o una proteína diana fúngica o una proteína diana procariota tales como una proteína diana bacteriana). Estos compuestos se unen con proteínas presentadoras intracelulares endógenas, tales como FKBPs o ciclofili
