The present invention provides an application of a combination of traditional Chinese medicine in the preparation of a potassium ion channel modulating agent. The combination of traditional Chinese medicine is made up of traditional Chinese medicine raw materials according to the following weight proportion:Coptidis Rhizoma250~450Sophorae Flavescentis150~350RadixPinelliae Rhizoma150~350Artemisiae Annuae Herba150~350Poria150~450Ginseng Radix Et Rhizoma 65~265Aurantii Fructus 65~265Ophiopogonis Radix150~350ImmaturusDichroae Radix150~350Glycyrrhizae Radix Et 65~265Nelumbinis Plumula10~70RhizomaThe combination of traditional Chinese medicine of the present invention could prolong the action potential interval of the myocardial cells, thereby prolong the refractory period of myocardial electrical activity. It has the function of inhibiting arrhythmia induced by excitatory reentry without toxic side effects. The invention provides a new medicine for the treatment of ventricular, atrial or ventricular arrhythmias, and it has a good application prospect. The invention is easy to be operated and suitable for large-scale production.
