Pieter R. Cullis,Igor V. Jigaltsev,James R. Taylor,Timothy Leaver,Andre Wild,Nathan Maurice Belliveau
申请号：
US14353460
公开号：
US20140328759A1
申请日:
2012.10.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Various lipid nanoparticles are disclosed, including nanoparticles comprising a lipid bilayer comprising a phospholipid, a sterol, a polyethylene glycol-lipid surrounding an aqueous core which comprises a therapeutic and/or diagnostic agent and nanoparticles comprising a lipid monolayer surrounding a hydrophobic core. Of particular interest are limit size lipid nanoparticles with a diameter from 10-100 nm. Such lipid nanoparticles are the smallest particles possible for a specific particle composition. Methods and apparatus for preparing such limit size lipid nanoparticles are disclosed.
