Andreas BLUM,Dirk GOTTSCHLING,Armin HECKEL,Joerg P. HEHN,Bernhard SCHMID,Dieter WIEDENMAYER
申请号：
US14802235
公开号：
US20150361055A1
申请日:
2015.07.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula Iwherein Ar, R1 and R2 are as defined in the description and claims, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.
