Aya Jakobovits,Raju Kucherlapati,Susan Klapholz,Michael J. Mendez,Larry Green
申请号：
US14462499
公开号：
US20150250152A1
申请日:
2014.08.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and VK) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
