This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles. pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.本揭示內容係關於新穎四環狀化合物,其可用以調制個體中之組織胺受體。於一項具體實施例中之化合物為四環狀[4,3-b]吲哚。亦提供包含該化合物之醫藥組合物,在多種治療應用上使用該化合物之方法亦然,包括認知病症、精神病症、神經遞質所媒介之病症及/或神經元病症之治療。(無元件符號說明)
