To confirm the safety of a fermented papaya preparation in type 2 diabetic patients while determining its in vivo effect on respiratory burst in human peripheral-blood mononuclear cells to find further health advantages for the type 2 diabetic patients. A respiratory burst activity promoter for improving the production of reactive oxygen species (ROS) induced by NADPH oxidase and promoting respiratory burst activity in type 2 diabetic patients, comprising a fermented papaya preparation as an active ingredient.