Andre BLUMENSTEIN,Justin ICHIDA,Kevin C. EGGAN,Lee L. RUBIN
申请号：
US14898028
公开号：
US20160115447A1
申请日:
2014.06.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present inventions relate to methods and compositions useful for improving the efficiency of inducing the generation of neurons from non-neuronal cell types, for example, by contacting the cell or cell culture medium with one or more agents which inhibit Activin and/or PLK1 signaling. Also disclosed are methods for promoting neuron survival, for example, by inhibiting Activin and/or PLK1 signaling, and methods for promoting the survival of intermediates in a cell differentiation pathway, for example, by inhibiting Activin and/or PLK1 signaling.
