磺醯胺基吡咯醯胺衍生物及其用作治療Ｂ型肝炎之醫藥品的用途农业专利-农业学术服务平台

发明人:: VANDYCK, KOEN,范戴克　科恩,HACHE, GEERWIN YVONNE PAUL,哈赫　格尔温,哈赫　格爾溫,LAST, STEFAAN JULIEN,拉斯特　史蒂芬,ROMBOUTS, GEERT,隆包茨　基尔特,隆包茨　基爾特,VERSCHUEREN, WIM GASTON,维索尔伦　温,維索爾倫　溫,RABOISSON, PIERRE JEAN-M,范戴克科恩,哈赫格尔温,哈赫格爾溫,拉斯特史蒂芬,隆包茨基尔特,隆包茨基爾特,维索尔伦温,維索爾倫溫

摘要：: Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.具有式(A)之HBV複製之抑制劑包括其立體化學異構形式、以及鹽、水合物、溶劑化物，其中Ra至Rd、以及R5至R6具有如在此所定義的含義。本發明還涉及用於製備所述化合物之方法、包含它們的藥物組成物以及它們單獨或與其他HBV抑制劑相組合在HBV療法中之用途。