Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent. Also described are methods of making these new crystalline polymorphic forms as well as methods of using these polymorphic forms to treat cancer.L'invention concerne des formes polymorphes du 1,6-dibromo-1,6-didésoxy-dulcitol (dibromo dulcitol ou DBD), qui est un agent antitumoral connu. L'invention concerne également des procédés de production de ces nouvelles formes polymorphes cristallines ainsi que des procédés d'utilisation de ces formes polymorphes pour traiter le cancer.