The invention provides compositions or pharmaceutical compositions of novel high penetration compositions (HPC) of a parent compound 、 which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capable of being converted to parent drugs or parent drug-related compounds such as metabolites after crossing one or more biological barriers and thus can render treatments for the conditions that the parent drugs or parent drug-related compounds can. Additionally 、 the HPCs are capable of reaching areas that their parent drugs or parent drug-related compounds may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. For example 、 HPCs of NSAIA have demonstrated indications such as treating hair loss and bold. The HPCs can be administered to a subject through various administration routes、e.g.、locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.本發明係揭露一種母化合物之新穎的高滲透性組合物(high penetration compositions、HPC)或醫藥組合物，其可以高穿透性之效率跨越生物界限(biological barrier)。在跨越過一個或一個以上的生物界限之後，高滲透性組合物可以轉換為母藥(parent drug)或與母藥相關之化合物(像是代謝物)，因此可以提供如同母藥或與母藥相關之化合物所能提供的療效。此外，高滲透性組合物更可到達其母藥或與母藥相關之化合物無法進入的領域，或提供足夠的專注力給該目標領域，因此提供更新的療效。例如，非類固醇抗炎藥的高滲透性組合物已顯現出可治療掉髮及禿頭的跡象。高滲透性組合物可經由不同的路徑以提供給一標的物，例如，藉由高穿透性或有全身性地提供給一生物標的，局部地傳送至一狀況的發生地點，並且可以更快的速度進入血液循環中。
