Methods of treating cancers comprising FGFR1 gene amplification are provided. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent.本發明提供治療包含FGFR1基因擴增之癌症的方法。在一些實施例中,該等方法包括投與纖維母細胞生長因子受體1(FGFR1)細胞外域(ECD)及/或FGFR1 ECD融合分子。在一些實施例中,該等方法包括投與纖維母細胞生長因子受體1(FGFR1)細胞外域(ECD)及/或FGFR1 ECD融合分子與至少一種其他治療劑之組合。