Caius G. Radu,Johannes Czernin,Dean O. Campbell,Shahriar S. Yaghoubi,Nagichettiar Satyamurthy,Arnon Lavie
申请号：
US14354770
公开号：
US20140248212A1
申请日:
2012.08.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Embodiments of the invention include a PET/SPECT reporter gene system that uses enhanced non-immunogenic versions of a human mitochondrial thymidine kinase 2 expressed in cytoplasm to preferentially trap novel PET/SPECT radiolabeled L and D-enantiomer analogs of the natural substrate thymidine. Such highly sensitive, non-immunogenic reporter genes function in combination with a set of novel, radiolabeled probes in whole body molecular imaging applications using positron emission tomography (PET) or single photon emission computed tomography (SPECT).
