Process for the preparation of rufinamide

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专利权人:

Rajendra Narayanrao Kankan

发明人:

Rajendra Narayanrao Kankan,Dharmaraj Ramachandra Rao,Dilip Ramdas Birari

申请号：

US13063440

公开号：

US08183269B2

申请日:

2009.10.09

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to a process for the preparation of rufinamide of formula I, which process comprises: (i) reacting a 2,6-difluorobenzylhalide of formula II, wherein X is chloride, bromide or iodide, with an azide to obtain 2-(azidomethyl)-1,3-difluorobenzene of formula III (ii) reacting 2-(azidomethyl)-1,3-difluorobenzene of formula III with methyl propiolate to obtain methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV and (iii) reacting methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV with ammonia to obtain rufinamide of formula I.

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