KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
Sang Yong JON,Dong Yun LEE,Yong Hyun LEE,Do Hyun YOO,Won Sik JUNG
申请号：
US16343043
公开号：
US20200230261A1
申请日:
2018.05.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides hydrophilic bilirubin derivative particles containing a metal, a use thereof, and a preparation method therefor. The bilirubin derivative particles of the present invention form coordinate bonds with various metals, and thus can be used in MR diagnosis, CT diagnosis, photo-acoustic diagnosis, PET diagnosis, or optical diagnosis. The bilirubin derivative particles of the present invention can release an anticancer drug encapsulated therein to the outside by the combination with a platinum-based anticancer drug and the degradation by a stimulation of light/reactive oxygen species, and exhibit anti-inflammatory and anticancer activities, and thus the bilirubin derivative particles of the present invention have a concept of theranostics in which the bilirubin derivative particles can be for therapeutic uses as well as diagnostic uses.
