Jason Burch,Minghua Sun,Xiaojing Wang,Wesley Blackaby,Alastair James Hodges,Andrew Sharpe
申请号:
US14036160
公开号:
US09328106B2
申请日:
2013.09.25
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.