The present invention relates to the compounds in general formula (I), the pharmaceutical composition containing the compound, and its in drug, the application especially in pain therapy, wherein the deformation of the compound has different meanings.本發明涉及通式(Ⅰ)中的化合物、含所述化合物的藥物組合物,及其在藥物,特別是在疼痛治療中的應用,其中所述化合物的變形有不同的含義。