Singh, Manmohan,Skibinski, David A.G.,Wu, Tom Yao-Hsiang,Li, Yongkai,Cortez, Alex,Zhang, Xiaoyue,Zou, Yefen,Hoffman, Timothy Z.,Pan, Jianfeng,Yue, Kathy
申请号：
AU2011295853
公开号：
AU2011295853A1
申请日:
2011.09.01
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
