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Heterocyclic derivatives that have PGD2 receptor antagonist activity
专利权人:
Ltd.;Shionogi & Co.
发明人:
HATA, Kayoko,MASUDA, Manami,NAKAI, Hiromi,TANIYAMA, Daisuke,TOBINAGA, Hiroyuki,HATO, Yoshio,FUJIU, Motohiro
申请号:
ES12844230
公开号:
ES2601788T3
申请日:
2012.10.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I): ** Formula ** in which ring A is ring B is an aromatic carbocycle, a non-aromatic carbocycle, an aromatic heterocycle or a non-aromatic heterocycle; -X1>; = is -N>; = or -C (R1)>; =; -X2>; = is -N>; = or -C (R2)>; =; -X3>; = is -N>; = or -C (R3)>; =; -X4>; = is -N>; = or -C (R4)>; =; -X5>; = is -N>; = or -C (R12)>; =; in which the number of "-N>; =" in the ring at -X1>; =, -X2>; =, -X3>; = and -X4>; = is 0, 1 or 2; R1, R2, R3 and R4 are each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted unscented carbocyclyl, substituted aromatic heterocyclyl or unsubstituted, or substituted or unsubstituted non-aromatic heterocyclyl; or two groups selected from R1, R2, R3 and R4 that are attached to neighboring ring constituent carbon atoms are taken together to form substituted or unsubstituted alkylene which may be interrupted with one or two heteroatom (s); R12 is a hydrogen atom or substituted or unsubstituted alkyl; R5 is formula: -L-R9, in which R9 is carboxy, alkyloxycarbonyl, -CONHCN, -CONHSO2Me, -CONHOH, -CONHOMe, -CONHOt- Bu, -CONHOCH2Ph, -SO3H, -SO2NH2, -SO2NHMe, -NHCONH2, NHCONMe2, -P (>; = O) (OH) 2, - P (>; = O) (OH) (OEt), -P (>; = O) (OH) NH2, -P (>; = O) (OH) NHMe, -CONHSO2Ph, -SO2NHCOMe, -SO2NHCOPh, ** Formula ** -L- is substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, or substituted or unsubstituted alkynylene; R6 is each independently halogen, hydroxy, carboxy, formyl, formyloxy, sulfanyl, sulfino, sulfo, thioformyl, thiocarboxy, dithiocarboxy, cyano, nitro, nitroso, azido, amidino, guanidino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl , substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or
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