BERTHEL, STEVEN JOSEPH,FIROOZNIA, FARIBORZ,FISHLOCK, DANIEL,HONG, JUN-BAE,LOU, YAN,LUCAS, MATTHEW C.,OWENS, THIMOTHY D.,SARMA, KESHAB,SWEENEY, ZACHARY KEVIN,TAYGERLY, JOSHUA PAUL GERGELY
申请号：
CA2753341
公开号：
CA2753341C
申请日:
2010.02.25
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
This application discloses compoundsaccording to general Formula (A)wherein, variable Z* is defined as describedherein, which inhibit Btk. The compounds disclosedherein are useful to modulate the activityof Btk and treat diseases associated with excessiveBtk activity. The compounds are furtheruseful to treat inflammatory and auto immunediseases associated with aberrant B-cell proliferationsuch as rheumatoid arthritis. Also disclosedare compositions containing compoundsof Formula (A) and at least one carrier, diluentor excipient.
