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Quantum Converting Nanoparticles as In Vivo and In Situ Optical Electric Field Sensors
专利权人:
The Board of Trustees of the Leland Stanford Junior University
发明人:
Randy Mehlenbacher,Alice Lay,Rea Kolbl,Miriam Goodman,Jennifer Dionne
申请号:
US16381874
公开号:
US20190235002A1
申请日:
2019.04.11
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Quantum converting nanoparticles for electric field sensing are provided. In one example, by combining upconverting lanthanide ions with voltage responsive dyes, we generate an optical platform that displays intensity and spectrum changes in the presence of electric fields. Our particles enable local (down to 10 nm spatial resolution) mapping of electric fields with exceptional photostability. We can image and quantify in vivo and in situ electric fields in biological and material systems up to fields of ˜100 kV/cm.
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