СТЭНТОН Мэттью Дж. (US),БАДЗИК Брайан В. (US),БЬЮТНЕР Грегори Л. (US),ЛЯО Хунбяо (US)
申请号：
RU2013118224/04
公开号：
RU2013118224A
申请日:
2011.09.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A cationic lipid according to the formula A: where: r and independently from each other selected from H, alkyl (CC), and polyamine heterocyclyl, wherein said alkyl, heterocyclyl, and polyamine, optionally are substituted with one to three substituents selected from R , or R may be the taken together with the nitrogen to which they are attached to form a monocyclic heterocycle with 4-7 members optionally containing in itself, in addition to that nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic heterocycle optional O is substituted with from one to three substituents selected from R are independently selected from H and alkyl (CC), said alkyl is optionally substituted with from one to three substituents selected from R R independently is selected from halogen, R ", oR", SR ", CN, COR" or CON (R ") R" is independently selected from H and alkyl (CC), wherein said alkyl is optionally substituted with halogen and OH n represents 0, 1, 2, 3, 4 or 5 Lvybran of alkyl C-Ci alkenyl CC, said alkyl and alkenyl optionally are substituted with using one or more substituents selected from R iLvybran of alkyl C-Ci aklenila CC, said alkyl and alkenyl optionally are substituted with one or more substituents selected from R or any pharmaceutically acceptable salt, or a stereoizomer.2. Cationic lipid represented by A in formula of claim 1, wherein: r and R, are each methyl R is H n is 0 Lvybran of alkyl C-Ci alkenyl CC iLvybran of alkyl C-Ci alkenyl CC or any pharmaceutically acceptable salt, or a stere1. Катионный липид по формуле A:где:R1 и R2 независимо друг от друга выбраны из H, алкила (C1-C6), гетероциклила и полиамина, где указанный алкил, гетероциклил и полиамин, необязательно, являются замещенными одним-тремя заместителями, выбранными из R, или R1 и R2 могут быть взяты совместно с азотом, к которому они присоединены для образования моноциклического гетероцикла с 4-7 членами, необязательно содержащего в себе, в дополнение к данному азот
