Christopher P. Rusconi;Sanjoy K. Mahanty;Samuel C. Wolff;Catherine C. Redick;JULIANA M. LAYZER
发明人:
JULIANA M. LAYZER,Sanjoy K. Mahanty,Samuel C. Wolff,Catherine C. Redick,Christopher P. Rusconi
申请号：
US13274189
公开号：
US20120095085A1
申请日:
2011.10.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided are ligands which bind to and regulate the function of CLEC-2. Nucleic acid CLEC-2 ligands described herein are able to inhibit CLEC-2 mediated platelet aggregation and may also provide use in regulating CLEC-2-mediated processes such as thrombus formation, tumor metastasis, lymphangiogenesis, HIV dissemination, inflammatory response, cytokine production and phagocytosis. Also disclosed herein are modulator molecules which can reverse the activity of the CLEC-2 ligand both in vitro and in vivo and ex vivo.
