A platform for oxygen generation and delivery is disclosed. The platform includes a hydrophobic substrate with at least one hydrophilic region permeable to gas flow formed thereon having an oxygen generating compound embedded in the at least one hydrophilic region. The platform further includes a microfluidic network with an inlet and an outlet bonded to the hydrophobic substrate with at least one fluid exchange region fluidly coupled to the inlet and the outlet and substantially matching the least one hydrophilic region. The microfluidic network is configured to receive an oxygen rich fluid at the inlet, communicate the oxygen rich fluid to the at least one fluid exchange region to mix with the oxygen generating compound, causing a chemical reaction resulting in formation of oxygen and a chemical byproduct, and communicate the chemical byproduct to the outlet, where the oxygen is permeated out of the at least one hydrophilic region.
