(E) the pharmaceutical salt, preparation method of-N- [4- [[the chloro- 4- of 3- (2- pyridinyl methoxies) phenyl] amino] -3- cyano -7- ethyoxyl -6- quinolyls] -3- [(2R) -1- methylpyrrolidin- 2- yls] propyl- 2- acrylamides and its application in medicine农业专利-农业专业知识服务系统

专利权人:: JIANGSU HENGRUI MEDICINE CO.;上海恒瑞医药有限公司; LTD.;上海恒瑞醫藥有限公司;江蘇恒瑞醫藥股份有限公司;SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.;JIANGSU HENGRUI MEDICINE CO., LTD.;江苏恒瑞医药股份有限公司

摘要：: The present invention provide formula (I) shown in (E)-N- [4- [[the chloro- 4- of 3- (2- pyridinyl methoxies) phenyl] amino] -3- cyano -7- ethyoxyl -6- quinolyls] -3- [(2R) -1- methylpyrrolidin- 2- yls] propyl- 2- acrylamides pharmaceutical salt, preparation method and as therapeutic agent especially as the pharmaceutical applications of kinases inhibitor.本發明提供式(I)所示的(E)-N-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2R)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可藥用的鹽，其製備方法以及作為治療劑特別是作為蛋白激酶抑制劑的製藥用途。