THOORENS GREGORY,LECLERCQ BRUNO,CARLIN BRIAN,RILEY PETER J,GARCIA MIGUEL ANGEL
申请号：
IN2194/CHENP/2009
公开号：
IN2009CN02194A
申请日:
2009.04.21
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
A method for the preparation of microcrystalline cellulose containing tablets by roller compaction followed by tabletting is disclosed. A tablet formulation is converted to a dry granulate by roller compaction, and the dry granulate lubricated dry granulate and compacted to a tablet. The tablet formulation comprises at least one active, an microcrystalline cellulose containing material, and, optionally other pharmaceutically acceptable excipients. The microcrystalline cellulose containing material has a maximum primary compaction tensile strength of at least 9 MPa or at least 9.5 MPa and a secondary compaction tensile strength of at least 5 MPa, at least 5.5 MPa, or at least 6 MPa
