The present invention relates to a femoral compression system (14) for applying compression against a puncture site of a vessel in a patient, and a method for applying compression with a femoral compression system. The compression system (14) comprises an inflatable compression element (15) adapted to apply a pressure against the puncture site, a tightening unit (23) adapted to extend around a part of, or the whole of, the patients body to fixate and to tighten the compression element (15) against the puncture site, a pump (16) adapted to inflate the compression element (15), a valve (17) adapted to deflate the compression element (15), a pressure transducer (18) adapted to sense the pressure within the compression element (15). The system further comprises a blood pressure pulse detector (19) adapted to sense the patients blood pressure pulse and to generate a pulse signal in dependence thereto that is applied to a control unit (20) that is connected to the pump (16), valve (17) and pressure transducer (19), wherein the control unit (20) is adapted to control the pressure within the compression element (15) in dependence of the pulse signal, by applying control signals to said pump (16) and valve (17).
