NI, Chiyou,PARK, Minnie,SHAO, Bin,TAFESSE, Laykea,YAO, Jiangchao,YOUNGMAN, Mark
申请号：
MEP2017219
公开号：
ME02873B
申请日:
2012.08.31
申请国别(地区):
ME
年份:
2018
代理人:
摘要：
The present disclosure provides substituted pyrimidine compounds of Formula I: and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
