VIROTHÉRAPIE ONCOLYTIQUE ET IMMUNOTHÉRAPIE

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专利权人:

Baylor College of Medicine

发明人:

申请号：

EP18725690.4

公开号：

EP3612202A2

申请日:

2018.04.20

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus； (ii) a virus comprising nucleic acid encoding an immunomodulatory factor； and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

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