The Burnet Institute;Walter and Eliza Hall Institute of Medical Research
发明人:
Mireille Hanna Lahoud,Irina Caminschi,Ken Shortman,Jian-Guo Zhang,Mark Francis Van Delft,David Ching Siang Huang,Nicos Anthony Nicola,Alan Frederick Cowman,Mark Dexter Wright
申请号：
US14581874
公开号：
US20150265721A1
申请日:
2014.12.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to the identification of proteins which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.
