MACDONALD LYNN,STEVENS SEAN,GURER CAGAN,MURPHY ANDREW J.,HOSIAWA KAROLINA A.
申请号：
NZ62697911
公开号：
NZ626979A
申请日:
2011.06.22
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a mouse &lambda； light chain allele comprising an unrearranged human V&lambda； gene segment and an unrearranged human J&lambda； gene segment wherein the endogenous &lambda； light chain allele comprises a deletion in a first V&lambda；-J&lambda；-C&lambda； gene cluster and replacement, in whole or in part, of the V&lambda；-J&lambda； gene segments of a second cluster of the allele with human V&lambda； and J&lambda； gene segments which are operably linked to a mouse C&lambda； constant region gene.
