Provided herein is a system for delivery of a physiologically active agent to a user in need thereof, comprising: one or two appliances that correspond to an upper arch and/or lower dental arch of the user, each appliance comprising a labial/buccal side surface and a palatal/lingual side surface, a delivery module of a physiologically active agent, comprising the physiologically active agent, the one or two appliances comprise a body matrix of a polymeric material comprising polymeric shells, each shell having the geometry corresponding to one tooth of the dental arch(s) and configured to receive the one tooth, and the delivery module provides a controlled release of the physiologically active agent.
