DIMITRIS KALOFONOS,G. PATRICK STAHLY,ISABEL KALOFONOS,JASON A. HANKO,JEFFREY S. STULTS,REX A. SHIPPLETT,WILLIAM MARTIN-DOYLE
申请号：
BRPI0916889
公开号：
BRPI0916889A2
申请日:
2009.08.06
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.
