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固體分散體製劑
专利权人:
发明人:
HOSHINO, TAKAFUMI,星野贵史,星野貴史,KUSAKI, FUMIE,草木史枝,草木史枝,FUKUI, IKUO,福井育生,福井育生
申请号:
TW096114057
公开号:
TWI469802B
申请日:
2007.04.20
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
Provided are a granule or a tablet of a solid dispersion that allows a drug in a preparation to be rapidly dissolved without impairing the dissolution of the solid dispersion, and a method for producing the same. More specifically, provided are a granule of a solid dispersion comprising a poorly soluble drug, a water-soluble polymer, an excipient and a disintegrator, wherein a content of the water-soluble polymer is 1 to 10% by weight and a content of the disintegrator is 15 to 50% by weight a tablet of a solid dispersion comprising a poorly soluble drug, a water-soluble polymer, an excipient and a disintegrator, wherein a content of the water-soluble polymer is 1 to 5% by weight and a content of the disintegrator is 15 to 50% by weight and a method for producing a granule or tablet of a solid dispersion comprising spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a mixed powder of an excipient and a disintegrator, and granulating and drying the resultant preparation.本發明係提供一種在不損及固體分散體溶出性,可迅速溶出製劑中之藥物的固體分散體之顆粒劑或錠劑及其製造方法。提供一種含有難溶性藥物、水溶性聚合物、賦形劑及崩散劑之固體分散體的顆粒劑,該水溶性聚合物之含量為1~10質量%,且該崩散劑含量為15~50質量%之固體分散體之顆粒劑。又,提供一種含有難溶性藥物、水溶性聚合物、賦形劑及崩散劑之固體分散體之錠劑,該水溶性聚合物之含量為1~5質量%,且該崩散劑含量為15~50質量%之固體分散體之錠劑。更提供一種於賦形劑與崩散劑之混合粉末中含有使難溶性藥物經分散或溶解之水溶性聚合物溶液進行噴霧、造粒、乾燥所成之固體分散體之顆粒或錠劑之製造方法。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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