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DÉRIVÉ HÉTÉROCYCLIQUE PRÉSENTANT UN EFFET D'ACTIVATION DE L'AMPK
专利权人:
塩野義製薬株式会社; LTD.;SHIONOGI & CO., LTD.;SHIONOGI & CO.
发明人:
KOJIMA, Eiichi,児嶋 栄一,HINATA, Yu,日向 優,WADA, Toshihiro,和田 俊博,児嶋 栄一,日向 優,和田 俊博
申请号:
JPJP2015/080162
公开号:
WO2016/068099A1
申请日:
2015.10.27
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In formula (I): L represents NR2R3, SR7, SO2R8, a substituted or unsubstituted alkyl, or a substituted or unsubstituted alkenyl; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; R3 represents a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; R7 represents a hydrogen atom, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; R8 represents a hydrogen atom, a substituted or unsubstituted alkyl (but not an unsubstituted methyl or an unsubstituted ethyl), a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; Y represents a substituted or unsubstituted alkyl (but not an unsubstituted methyl or an unsubstituted ethyl), a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted aryl, or the like; Z represents –CR6= or –N=; R1 represents a hydrogen atom or a substituted or unsubstituted alkyl; and R4, R5, and R6 are each independently a hydrogen atom, a halogen, a hydroxyl, a cyano, a nitro, a carboxy, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like.)L'invention concerne un composé représenté par la formule (I) ou un sel pharmaceutiquement acceptable correspondant. (Dans la formule (I) : L représente NR2R3, SR7, SO2R8, alkyle substitué ou non substitué ou alcényle substitué ou non substitué ; R2 représente un atome d'hydrogène, alkyle substitué ou non substitué, alcényle substitué ou non substitué, alcynyle substitué ou non substitué ou analogue ; R3 représente alkyle substitué ou non substitué, alcényle substitué ou non substitué, alcynyle substitué ou
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