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ПЕРОРАЛЬНЫЕ ЕДИНИЧНЫЕ ЛЕКАРСТВЕННЫЕ ФОРМЫ И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ГОШЕ
专利权人:
ПРОТАЛИКС ЛТД. (IL)
发明人:
ШААЛТИЕЛ Йозеф (IL),ТЗАБАН Салит (IL)
申请号:
RU2014137404
公开号:
RU2014137404A
申请日:
2013.02.19
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method of treating Gaucher disease in a subject in need thereof comprising orally administering to the subject a therapeutically effective amount of recombinant glucocerebrosidase (GCD), contained in plant cells, wherein said therapeutically effective amount corresponds to GCD 1-1920 units / kg / 14 days, thus provides treatment Goshe.2 disease. A method of treating Gaucher disease in a subject in need thereof comprising orally administering to the subject a therapeutically effective amount of recombinant glucocerebrosidase (GCD), contained in plant cells, wherein the amount of said GCD units to 16 times, for example up to 4-16 times greater than the number GCD units administered by intravenous (i / v) injection, which thus provides, in the treatment of Gaucher disease subekta.3. A method of treating Gaucher disease in a subject need thereof comprising orally administering to the subject a therapeutically effective amount of recombinant glucocerebrosidase (GCD), contained in plant cells, wherein said administration is carried out before a meal or after a small amount of food, so that the pH value in the stomach exceeds 2, which thus provides a treatment Goshe.4 disease. The method of claim 1 or 2, characterized in that said administration is carried out before a meal or after a small amount of food, so that the pH value in the stomach of said subject exceeds 2.5. The method of claim 3, characterized in that the administration is at a dosage of 1-1920 units / kg.6. A method according to any one of claims. 1-3, characterized in that the administration is at a dosage of 100-1200 units / kg, or optionally 120-960 units / kg, or optionally 300-600 edi1. Способ лечения болезни Гоше у субъекта с потребностью в этом, включающий пероральное введение субъекту терапевтически эффективного количества рекомбинантной глюкоцереброзидазы (GCD), содержащейся в растительных клетках, при этом указанное терапевтически эффективное количество GCD соответствует 1-1920 единиц/кг/14 дне
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