Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source (18) comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape (74) having the drug disposed thereon. The device also includes a first collimator (40) fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.
